One-gene-one-enzyme: Remembering biochemical genetics

The origins of molecular genetics: one gene, one enzyme.

The discovery that individual genes represent individual polypeptides was made twice. In 1902, Archibald Garrod, an English physician, published a paper in which he called attention to the fact that alcaptonuria, a rare disease of man characterized by the lifelong excretion of homogentisic acid, is hereditary. He cited William Bateson, the leading British proponent of the just-rediscovered scie...

The one gene-one enzyme hypothesis.

Genomics in Neurospora crassa: From One-Gene- One-Enzyme to 10,000 Genes

Neurospora crassa was the central organism in the development of biochemical genetics, providing a model system that established the relationship between genes and enzymes; it remains the best-studied filamentous fungus. This review focuses on the impact that the recent publication of a high-quality draft sequence of the N. crassa genome will have upon efforts to understand the biology of the f...

The favorable features of tryptophan synthase for proving Beadle and Tatum's one gene-one enzyme hypothesis.

LAST year we celebrated the 100th anniversary of the ing Beadle and Tatum’s proposal of the one gene–one enzyme relationship, our understanding of the strucbirth of George Beadle. He, with Edward Tatum, in 1941, proposed one of the major conceptual advances in tural features of genes and enzymes was insufficient to allow formulation of a finite molecular relationship. biology in the 20th centur...

One verse, One Concept

No Abstract